By Alexander Shulgin, Ann Shulgin
Ebook I: the affection Story
Tells the story of a psychopharmacologist and his wife/research associate, and recounts a long time dedicated to the construction and research of psychedelic medicinal drugs as instruments for the learn of the human brain. Altered nation reports are explored within the context of intimacy.
Book II: The Chemical Story
Describes intimately a wealth of phenethylamines:
• Synthesis and actual properties
(in the structure of the magazine of Medicinal Chemistry)
• Structural correlates to human important worried approach activity
• The dosages used and length of results observed
• remark and hypothesis on why (for instance):
a few which must have been lively, are not
a few which do not need been lively, are
a few are too poisonous to figure out activity
And a few haven't begun to be tasted
Read Online or Download Pihkal: A Chemical Love Story PDF
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Il presente quantity raccoglie tre saggi del filosofo tedesco a proposito del magnetismo animale, del destino dell'individuo e delle apparizioni di spiriti. Schopenhauer ne illustra i contenuti essenziali alla luce della sua dottrina fondamentale: los angeles volontà sta alla base ed è l'origine di ogni cosa e pertanto l. a. natura, ovvero il mondo fenomenico, è solo l. a. manifestazione di story principio.
Publication I: the affection StoryTells the story of a psychopharmacologist and his wife/research associate, and recounts many years dedicated to the production and research of psychedelic medicines as instruments for the learn of the human brain. Altered nation stories are explored within the context of intimacy. e-book II: The Chemical StoryDescribes intimately a wealth of phenethylamines:• Synthesis and actual houses (in the structure of the magazine of Medicinal Chemistry)• Structural correlates to human principal worried approach task• The dosages used and length of results saw• remark and hypothesis on why (for instance): a few which must have been energetic, should not a few which would not have been lively, are a few are too poisonous to figure out activityAnd a few haven't begun to be tasted
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Additional resources for Pihkal: A Chemical Love Story
After much diddling and fiddling around, this set up as a crystalline mass. 3 g of the crude nitrostyrene as an orange crystalline residue product after air-drying. 3 g crude 1-(2,5-dimethoxy-4-phenylthiophenyl)-2-nitropropene as yellow crystals, with a mp of 100-102 °C (with prior sintering at about 98 °C). This was recrystallized from 50 mL boiling 95% EtOH. After cooling in an ice bath, it was filtered, washed with EtOH, and air drying provided goldyellow crystals with a mp of 105-106 °C. The proton NMR was excellent (in CDCl3).
Recrystallization from IPA gave an analytical sample with a mp of 204-205 °C. Anal. 52. DOSAGE: 5 - 10 mg. 02 19:59:10] Erowid Online Texts : PiHKAL #3 ALEPH DURATION: 6 - 8 h. QUALITATIVE COMMENTS: (with 5 mg) The initial hints of action were physical--warming of first the legs, and then a comfortable warmth spread over the entire body. Intense intellectual stimulation, one that inspired the scribbling of some 14 pages of handwritten notes. Which is a pretty good record for an experience that is almost entirely non-verbal.
But there are lots of syndromes that involve a state of mind, and these are uniquely human. Many of the psychopharmacological anti-this or anti-that agents address ailments such as anxiety, psychosis, paranoia, or depression, which are only known in man. So how does one discover a new drug in areas such as these? If one has in hand a drug that is known to be effective in one of these human ailments, an animal assay can be set up to give some measurable response to that specific drug, or a biochemical property can be rationalized as being related to a mechanism of action.